So, I was sitting in class…

…and Dr. Ryerse was talking to us about Gap Junctions. Basically, these are connections between cells that are made up of proteins. Think of them like connecting two pieces of cloth with a hollow rivet… They are very important in a variety of cellular functions, but perhaps most importantly, in synchronizing all of the cells in the heart (and muscle in general) to make one single contraction and pump our blood.

Anyway, in talking about these, he brought up a few points (most of which I can’t remember…) that got me thinking about how much of ourselves we know nothing about. In the physical sense, our bodies “just work”…but how and why? I mean, we go walking around every day and the general public doesn’t know (or care…) about how the cells in our heart know how to contract at the same time and pump our blood.But we’ve been working on “science,” in the general sense of the word, for thousands of years yet we’ve only scratched the surface.
Shouldn’t we care about these things? Shouldn’t we be more interested in learning all that there is to know about our bodies, so we know how to fix the problems there, rather than the problems between bodies in foreign countries? If I remember right, Bush plans on cutting a variety of programs, generally social, educational and scientific interests, in favor of more money to finance his Iraq vendetta. Does this make sense?
I guess it’s just human nature, but here’s the point: people don’t care how something works, only that it continues to work. People don’t care about science until it affects them. Funding for scientific endeavours is only readily available to people working on health-related fields, while funding for other research (such as ecology, sociology, etc.) is harder to come by. We save the minimal amount of funding to pay for “important” things like helping fix lung cancer (caused by cigarettes) or funding faster propulsion (so we can blow up other countries) or funding research into lower emission vehicles (because we have to drive big SUVs rather than using the smaller vehicles we already have).

Seriously, I think if the USA just saved a third of the money being poured into Iraq and other worthless ventures (congressional salaries, military stockpiling, tax cuts for the rich, etc.) and instead put it into general scientific (physics, biology, chemistry…) and social (arts, humanities…) research, the world would get a lot better really quickly.

At the very least, we, as a culture, would be seen as less hypocritical in the eyes of our enemies…’cause that’d solve a lot of other problems…

…it’s amazing what thoughts can come out of a discussion on gap junctions, eh?

One more rotation…

So on Monday afternoon, I’m starting my fourth (and final?) rotation with Dr. Heather Macarthur. I’m actually pretty excited about this rotation since, for the first time, I’m doing research in stuff I’m pretty interested in. I wanted to go to SLU because of the research going on in Dr. Westfall’s lab, and Dr. Macarthur works really closely with him…thus, the research is similar…

Here’s the rundown: Parkinson’s Disease is characterized by a loss of motor control because (so far as we know) neurons localized in your brain (acround the cerebellum and nucleus accumbens…I think…) die for some reason. It is thought that one way these neurons die is due to oxidative stress. For those of you who know anything about chemistry, there are things called “free radicals,” which are analogues of known compounds that are missing an electron…hence, they “want” to bind with something else by any means necessary. In the body, these free radicals can do a lot of damage and can end up damaging or killing a given cell. We take antioxidants (and we have natural ones in our bodies…) to prevent damage by free radicals…surely you’ve heard of those…
Well, dopamine is a neurotransmitter that is important in controlling our body movements in our brain (among other functions). Apparently, there is a “version” of dopamine known as dopaminochrome that is essentially a dopamine free radical… If this stuff accumulates in your brain, it can kill off the cells it inhabits…and in Parkinson’s patients, it is possible that this molecule ends up accumulating where dopamine is normally localized.

(side note: as Dr. Macarthur pointed out to me, we normally think of Parkinson’s patients as moving uncontrollably. Actually, Parkinson’s patients would normally not be able to move at all, but the drugs we give them flood the cells with dopamine, causing more uncontrollable movement. I didn’t know that…thought it was interesting… :-P)

Anyway, Dr. Macarthur’s lab works with dopaminochrome in rats, detecting it and analyzing its effects. Actually, they use a drug that causes Parkinson’s-like effects in rats or cell lines, which allows for testing. I’m not sure exactly what I’ll end up doing in her lab, but I think I’ll be messing with an HPLC (high pressure liquid chromatography) that’s been modified to detect dopaminochrome in a variety of situations… If all goes well, then I’ll be doing this stuff for the next 4 years until I get a Ph.D… 😛

LNSEMSF

Courtesy of Steve Hosack, I present to you the Leonard Nimoy Should Eat More Salsa Foundation official website. If any of you actually have souls, you should join.

From the site:

“We here at the LNSEMSF believe that Leonard Nimoy is excellent, and salsa is excellent, and if Leonard Nimoy would eat more salsa, he would become an unstoppable force of excellence. For anybody doubting this belief, we have researched the projected level of Leonard Nimoy’s excellence with and without salsa.”

They even have data to support their findings.? I’m in awe…